TA Instruments – RS-DSC
The TA Instruments RS-DSC (Rapid Screening Differential Scanning Calorimeter) is an advanced thermal analysis instrument designed for high-throughput thermal stability testing in biologic drug development. It offers precise and efficient measurement of biomolecule stability, enabling researchers to ensure product quality and accelerate development timelines. Tailored for high-concentration biologic formulations, it addresses the specific needs of antibody drugs and engineered proteins.
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The RS-DSC from TA Instruments is more than just a DSC; it’s a rapid screening solution built for high throughput environments. Here’s why the RS-DSC stands out as the top choice for high throughput DSC
Key Features
- Enhanced Throughput: The TA Instruments RS-DSC enables the analysis of 24 samples simultaneously which significantly speeds up research and accelerates biologic drug market entry.
- Resource Efficiency: The TA Instruments RS-DSC’s minimal sample volume requirements help ensure maximum material use and minimize cost.
- High Concentration Proficiency: The TA Instruments RS-DSC excels in testing an extensive range of sample concentrations and has a unique capacity for analyzing very high concentration drug products efficiently and effectively.
- Simplified Workflow: The TA Instruments RS-DSC streamlines operations by removing the need for sample dilution when working with high-concentration samples, and the disposable microfluidic chips reduce or eliminate the need for cleaning and reduce the risk of contamination.
- Comprehensive Data Analysis: NanoAnalyze Software manages data and provides detailed insights to optimize development.
Technical Specifications
| TA Instruments RS-DSC | |
| Cell Geometry | Disposable microfluidic |
| Cell Material | Glass |
| Sample Format | MFC (Micro Fluidic Chips) |
| Working cell volume | 11 µL |
| Sample Capacity | 24 MFCs |
| Typical Sample Concentration | 20 mg/mL – 330+ mg/mL IgG (protein dependent)1 |
| Sample throughput | > 96 samples/day |
| Temperature Range | 20-100 °C |
| Temperature Scan Rate | 1 or 2 °C/min |
| Temperature accuracy | ± 0.2 °C (across all calorimeters); ± 0.1 °C reproducibility2 |
| 1Using lysozyme in 0.1 M glycine buffer at pH 2.5 or IgG in PBS at pH 7.4 at 1 °C/min 2 Using DPPC in water at pH 7 at 1 °C/min |
TA Instruments RS-DSC
TA instruments provides innovative material characterization instruments that are widely used for research, analysis, and quality control in the evaluation…
