TA Instruments – Isothermal Titration Calorimeters
Isothermal titration calorimetry (ITC) is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The method determines a binding constant, reaction stoichiometry, and total reaction energy of two or more compounds (small or large molecules) in solution. Isothermal titration calorimeters do this by measuring the heat that is released or absorbed when molecules interact with each other.
Available in :
Temperature conditions can be controlled to understand the temperature dependence of binding.
Key Features
- AccuShotโข delivers the titrant to the right location for the best mixing
- FlexSpinโข provides innovative slow speed stirring, efficient mixing and highest sensitivity
- Fully automated, user-selectable system cleaning routines eliminate run-to-run contamination
- Intelligent Hardware Positioning for precise reliable injections
- Solid-state active heating and cooling for true isothermal temperature control
- Choice of standard volume (1.0 mL) or low volume cells (190 ยตL)
- Industry proven 96-well, temperature-controlled liquid handling autosampler. Autosampler can be included with initial purchase or added at a later date
- Powerful ITCRun and NanoAnalyze for the most comprehensive suite of tools for method optimization, model fitting, batch analysis, graphing and data export
Technical Specification
| Affinity ITC | ||
| Standard Volume | Low Volume | |
| Minimum Detectable Heat | 0.1 ยตJ | 0.04 ยตJ /0.05 ยตJ |
| Maximum Measurable Heat | 5,000 ยตJ | 5,000 ยตJ |
| Low Noise Level | 0.0025 ยตWatt | 0.0013 ฮผW/ 0.0014 ยตWatt |
| Baseline Stability | 0.02 ยตWatt/hr | 0.02 ยตWatt/hr |
| Nano ITC | ||
| Standard Volume | Low Volume | |
| Sample Cell Size | 1.0 mL | 190 ยตL |
| Injection Syringe Volume | 100 ยตL & 250 ยตL | 50 ยตL |
| Cell Geometry | Fixed Cylindrical | Fixed Cylindrical |
| Cell Composition | 24K Gold / Hastelloy | 24K Gold |
Available Models
The Affinity ITC and ITC Auto are designed for the most challenging life science laboratory environments that require high sensitivity, high productivity and the most advanced ITC technologies. The Affinity ITC, along with the Nano DSC, are used in gene therapy applications for characterizing serotype and drug loading in AAVs and LNPs, as well as target and off-target binding interactions. The Affinity ITC brings advanced engineering to all critical aspects of the measurement ensuring the highest quality ITC data.
Key Features
- AccuShotโข delivers the titrant to the right location for the best mixing
- FlexSpinโข provides innovative slow speed stirring, efficient mixing and highest sensitivity
- Fully automated, user-selectable system cleaning routines eliminate run-to-run contamination
- Intelligent Hardware Positioning for precise reliable injections
- Solid-state active heating and cooling for true isothermal temperature control
- Choice of standard volume (1.0 mL) or low volume cells (190 ยตL)
- Industry proven 96-well, temperature-controlled liquid handling autosampler. Autosampler can be included with initial purchase or added at a later date
- Powerful ITCRun and NanoAnalyze for the most comprehensive suite of tools for method optimization, model fitting, batch analysis, graphing and data export
The Nano ITC Standard Volume and Nano ITC Low Volume isothermal titration calorimeters are designed to provide maximum sensitivity and flexibility for the study of biomolecular binding. Both instruments use solid state thermoelectric heating and cooling systems to precisely control temperature, and have the same flexible injection syringe assemblies for efficient and accurate delivery of titrant. The true isothermal power compensation design of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analyzing biological samples in-solution.
Key Features
- Choice of Standard Volume (1.0 mL) or Low Volume (190 ยตL) cells
- Solid-state active heating and cooling for true isothermal temperature control
- High precision injection buret for accurate titrant delivery
- Unique removable injection syringe for fast, reliable loading and cleaning
- Powerful ITCRun and NanoAnalyze for the most comprehensive suite of tools for method optimization, model fitting, batch analysis, graphing and data export
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