SARTORIUS – Crossflow

Tangential Flow Filtration (TFF) Process Solutions

Spanning production capacity needs with maximum equipment utilization. Mitigate the risk of operator error and significantly reduce your development time in both single-use or hybrid processes. Our solutions provide high-performance from process development to commercial manufacturing in various upstream and downstream bioprocessing steps, including cell harvest, clarification, perfusion, ultrafiltration, and diafiltration.

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Overview

Features

Specifications

Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials, from laboratory environments up to commercial production batches. The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for aseptic processing.

Key Features

PD & Bench scale up to Pilot to Commercial scale
Membrane area 10 cm² – 10 m²
Ultrafiltration and Microfiltration cassettes
Single use and Multiuse

Technical Specifications

Model	Ambr® Crossflow	Sartoflow® Smart	Sartoflow® Advanced	Sartoflow® 150	Sartoflow® Expert SU	Sartoflow® 1000	Sartoflow® 4500
Membrane Area	10, 50 cm²	50 cm² – 0.14 m²	0.1 – 0.21 m²	0.1 – 0.4 m²	0.1 – 0.4, 1.4 m²	0.6 – 2.8 m²	Up to 10 m²
Vessel Volume	100 mL	1 L with mixing	10 L	5, 10, 20 L	20 L mixing	10, 20, 100 L
Flow Rate / Pump Capacity	0 – 80 mL/min	1 – 100 L/h	700 L/h	5 – 150 L/h	900L/h	20 – 1,000 L/h	00 – 4500 L/h
Minimum Recirculation Volume	5 mL	< 20 mL	~ 170 mL	130 mL	~ 600 mL	~ 1.2 L	Depends on bag size
Automation Level	Fully	Semi	Fully	Fully	Fully	Fully
Process Mode (multi/single)	Multi-use or single-use	Multi-use	Multi-use	Single-use	Single-use	Single-use