RedShiftBio – Microfluidic Modulation Spectroscopy (MMS) – AQS³pro
RedShiftBio’s AQS³pro overcomes many of the limitations of traditional spectroscopy-based technologies with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules.
AQS³pro can be used for a wide range of applications from formulation development of mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA. Powered by Microfluidic Modulation Spectroscopy (MMS), the AQS³pro is designed to provide five key measurements— aggregation, quantitation, stability, similarity, structure—directly supports biomolecule characterization throughout the biopharmaceutical development pipeline.
Key Features
- Ability to measure wide range of native sample concentrations from <0.1 mg/ml to >200 mg/ml
- Fully automated sample-handling, with both 24 and 96 well plate formats
- Real-time background subtraction eliminates need to dialyze samples
- Detection of <2% change in secondary structure even at low concentrations
- Advanced onboard data analytics enabling rapid and robust data interpretation and reporting
Technical Specifications
| System Summary | |
| Measurement Method | Microfluidic Modulation Spectroscopy |
|---|---|
| Measurement Type | Mid-Infrared Absorption |
| Supported Protein Measurements | Secondary Structure, Similarity, chemical and quenched |
| Sample | |
| Concentration Range | 0.1 to >200 mg/mL |
| Typical Repeatability | >98% with 2 mg/mL Lysozyme in water (area of overlap) |
| Dimensions and Weights | |
| Analyzer Unit | 22 H x 18.25 W x 18.5 D, 80 lbs |
| Electronics Unit | 25 H x 10.5 W x 18 D, 40 lbs |
The Benefits Of Microfluidic Modulation Spectroscopy (MMS)
MMS is a novel technology for label-free biomolecule analysis of protein aggregation, quantitation, stability, structure and similarity that directly addresses the limitations of current technologies. MMS provides drift-free, background subtracted, high sensitivity measurements of the protein secondary structure to facilitate major improvement in development of biopharmaceuticals.
AQS³pro
- 30x sensitivity to detect pivotal changes in structure over wide concentration ranges compared to traditional FTIR.
- Fully automated sample-handling system with 96-well plate option.
- Outstanding reproducibility that enables biomolecule analysis in complex buffers.
- Inbuilt advanced data analytics enabling rapid and robust data interpretation and reporting, with an optional 21-CFR part 11 data compliance package.
- Reducing development time.
- Improving product quality.
- De-risking development.
- Increased confidence in data quality which leads to more efficient decision making.
- Optimizing process design and development.
Learn about the AQS³pro – The Next Generation in Protein Characterization
RedShiftBio is redefining the possibilities for structural characterization of biomolecules. RedShiftBio has developed a proprietary life sciences platform combining our…
