Corning – 3D Clear Tissue Clearing Reagent
Clear 3D Cell Culture Models With Minimal Changes to Morphology and Without Compromising Sensitivity
Despite the growing relevance of 3D cell culture as a research model, imaging techniques used to characterize these models are highly limited. Due to the thickness and opacity of 3D cellular structures, most current imaging technologies cannot penetrate to the center of the tissues, resulting in only the outer 2 to 3 layers of cells being detected. This causes the dark centers often seen in images of 3D cell culture models, which proves highly problematic for accurate analysis as these outer cells are most exposed to compounds, nutrients and oxygen and thus do not reflect the entire cell population.
Corning now offers 3D Clear Tissue Clearing reagent that can be used in a tissue clearing technique, designed specifically to support imaging for 3D cell culture models and plate-based high throughput processing. When paired with fluorescent labeling (e.g., fluorescent protein, immunofluorescence, chemical dyes) and high content confocal microscopy, Corning 3D Clear reagent allows for complete 3D cell culture model characterization and more accurate drug screening.
Key Features
Applications
Research Applications for the 3D Clear Tissue Reagent
Organoid Culture Models
Corning 3D Clear can be used for clearing organoid models to enable optimal clarity for sharp, clear cell images.
Disease Modeling
Disease models support our understanding of how disease develops and progresses, as well as potential treatment approaches.
Spheroid Models
3D multicellular spheroids can develop metabolic gradients that create heterogeneous cell populations with superior cell-to-cell and cell-to-ECM interactions.
Drug Discovery
Enhance your assay development and performance.
Cancer Research
Corning supports this important research with reliable lab products that deliver consistent, repeatable results.
Brand
Corning Incorporated is a leading innovator in materials science. For nearly 170 years, Corning has combined its unparalleled expertise in glass science, ceramic science, and optical physics with deep manufacturing and engineering capabilities to develop category-defining products that transform industries and enhance people’s lives.
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