Buchiglas – HPAPI reactor & process systems
High containment glass reactor systems for safe handling and synthesis of highly potent APIs (HPAPIs) in process development, kilo labs and small-scale production. Compact footprints fit isolators and glove boxes, CIP spray nozzles enable residue-free cleaning, and with split valves to minimize exposure (OEL/OEB). Fully customized and engineered according to your operational requirements and smartly integrated into glove boxes & isolators. Full compliance with cGMP requirements and regulations such as ATEX and PED.
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Customized HPAPI process equipment for maximum safety and productivity
Büchi AG is a leading Swiss manufacturer of reactor systems, pilot plants, and high-containment solutions for HPAPI (Highly Potent Active Pharmaceutical Ingredients). With decades of expertise, we design equipment that ensures maximum operator safety and optimal process performance.
Our HPAPI process systems comply with strict cGMP requirements and ATEX regulations. We supply equipment from R&D through scale-up to production scale.
Technical Specifications
Volume range: 5 to 250 liters
Pressure range: -1.0 to +0.5 bar
Temperature range: -90 °C to +200 °C
Materials (options): Borosilicate glass 3.3, glass-lined steel, Hastelloy® PTFE, PFA, PEEK
ATEX (explosion-proof) compliant
CIP (clean-in-place) capabilities for reduced downtimes
Key Features
- Maximum tightness and easy cleaning thanks to optimized designs.
- Seamless integration into containment systems or isolators, in cooperation with leading manufacturers.
- Use of high-performance materials, including borosilicate glass 3.3, glass-lined steel, fluoropolymers, and Hastelloy® for outstanding chemical resistance.
- Proprietary flexible glass piping system buchiflex for leak-tight connections and maximum flexibility during operation.
Benefits of HPAPI process equipment
Choosing HPAPI reactor systems from Büchi AG offers more than just reliable equipment. These systems are designed to guarantee saftey, efficiency, and compliance at every stage of your process.
Some of the key advantages:
- Fully customized to meet your specific process and operational requirements.
- High cleanability, ensuring consistent product quality batch after batch.
- Maximum operator safety through reliable containment.
- Full compliance with requirements of cGMP and applicable regulations such as ATEX and PED.
- Comprehensive documentation, including IQ/OQ protocols and a quality project plan (QPP), for smooth validation and regulatory approval.
HPAPI process equipment design features
To meet the strict cGMP requirements of pharmaceutical production, our process equipment designs include the following features:
- Polished stainless steel components for improved cleanability
- Encapsulated motors without external ventilation to avoid air turbulances and to enable outside cleaning with liquids
- Polished stainless steel valves bodies and handles
- buchiflex flanges in polished stainless steel
- Cover plates in Hastelloy® or stainless steel
Buchiglas is a Swiss engineering and manufacturing company specializing in reactor systems, pilot plants, and process equipment for the chemical,…
