Buchiglas – Filter reactors for pilot plants and kilo labs
Multipurpose filter reactors that combine synthesis, crystallization / purification in one system. Features include removable filter cloths, heating jackets and heated bottom plates for efficient and optimized heat transfer during any process. Built from borosilicate glass 3.3, fluoropolymer coated stainless steel or Hastelloy® and tailored according to your process requirements. Full compliance with cGMP requirements and regulations such as ATEX and PED.
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Filter reactors for pilot plants and kilo labs
Our innovative filter reactors are specifically designed for pilot plants and kilo laboratories. These systems combine a reactor and a nutsche filter in a single unit, enabling a wide range of processes and applications, including cGMP API synthesis, peptide synthesis (peptide synthesizer), and cannabis extraction.
The filter reactors are available in three sizes, with 10 liter, 30 liter, and 50 liter reaction volumes. They feature a modular design that allows for easy configuration to meet your specific process requirements.
Technical Specifications
Filtration vessel: 10, 30, 50 liter
Pressure FR 10: -1.0 (FV) to +1.0 bar
Pressure FR 30, FR 50: -1.0 (FV) to +0.5 bar
Temperature: -60/+200 °C
Key Features
- Maximum tightness and easy cleaning thanks to optimized designs.
- Seamless integration into containment systems or isolators, in cooperation with leading manufacturers.
- Use of high-performance materials, including borosilicate glass 3.3, glass-lined steel, fluoropolymers, and Hastelloy® for outstanding chemical resistance.
- Proprietary flexible glass piping system buchiflex for leak-tight connections and maximum flexibility during operation.
Applications
- Chemical synthesis
- Cannabis solvent extraction
- Evaporation / precipitation / crystallization
- Scale-up
- Filtration / washing / drying
- Solid phase peptide synthesis (SPPS)
- cGMP API production
Base filter reactor system
Complete, ready-to-run setup for reaction, filtration, and cake discharge.
- Reaction vessel: Borosilicate glass 3.3 with integrated heating/cooling jacket
- Structure & sealing: Durable cover plate and bottom plate made from stainless steel with PFA coating
- Drive & agitation: Dry-running mechanical seal with ATEX-certified stirrer drive
- Mixing system: Multi-stage stirrer and baffle with integrated Pt100 temperature sensor (PFA coated)
- Cake discharge: Manual 2-step lowering device for vessel and bottom plate with swing-out mechanism
- Connectivity: Pull-safe TCU connection ports, heating hoses, and flexible, vacuum-tight buchiflex glass piping
Process adaptations & peripherals
Customized options for your process requirements, including but not limited to:
- Glass overhead: 4 modular glass upper section (GUS) configurations or fully customized designs
- Material upgrades: Cover plate, bottom plate, and stirrer available in stainless steel 1.4404 or Hastelloy® C22
- Thermal filtercake drying: Heated bottom plate for improved heat transfer (stainless steel 1.4404 or Hastelloy® C22)
- Process monitoring & control: Integration of sensors for temperature, pressure/vacuum, stirrer speed, and pH
- Liquid handling & peptide synthesis: Automated reagent dosing and solvent washing steps for solid-phase synthesis (SPPS)
- Process sampling: Sampling device
- Cleanroom & cleaning: Cleanroom design for highly potent active pharmaceutical ingredients (HPAPIs) and CIP spray nozzle
Filter reactor for scale-up & pilot plants
Buchiglas is a Swiss engineering and manufacturing company specializing in reactor systems, pilot plants, and process equipment for the chemical,…
