heliX® measures conformational changes in real-time by directly comparing the hydrodynamic friction (switching speed) of two molecules on two adjacent sensor spots.
Conformational changes are expressed as %-friction-change, which works …
heliX® measures conformational changes in real-time by directly comparing the hydrodynamic friction (switching speed) of two molecules on two adjacent sensor spots.
Conformational changes are expressed as %-friction-change, which works for any protein or nucleic acid state in almost any environment. Hence, molecular conformations can be investigated early in the discovery process, without previous knowledge about a sample.