Associates of Cape Cod – Recombinant Cascade Reagent (rCR) Assay
PyroSmart NextGen™ recombinant Cascade Reagent (rCR) marks the introduction of a new sustainable recombinant LAL reagent technology for Bacterial Endotoxin Testing (BET). Utilizing the same LAL cascade as traditional LAL reagents, while eliminating the potential for 1,3-β-D-glucans cross reactivity, PyroSmart NextGen™ delivers all of the quality and consistency of results you have come to expect from ACC LAL reagents.
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PyroSmart NextGen™ can be used for a wide variety of endotoxin tests, ranging from standard water testing to samples requiring high sensitivity, such as intrathecal products and those requiring high dilutions to overcome interference.
Key Features
- Test Performance: The PyroSmart NextGen™ reaction mixture is incubated at 37±1°C and read in a microplate reader equipped with a 405–410 nm filter. The time of incubation is dependent on the lowest standard concentration in the standard curve, with 0.005 EU/mL achievable in 2500 seconds in a microplate reader. Software is used to construct the standard curve and calculate the endotoxin concentrations.
- Product Stability: PyroSmart NextGen™ is a lyophilized product with an excellent shelf life of 3 years from the date of manufacture.
- Product Reconstitution: PyroSmart NextGen™ is provided as co-lyophilized with the chromogenic substrate and as such it is ready-to-use following a simple reconstitution (using 2.8mL of the supplied reconstitution buffer).
- Product Packaging: PyroSmart NextGen™ reagent is provided as a pack of 2 vials of reagent and 2 vials of reconstitution buffer. This is sufficient for a total of 110 wells (55 wells per vial).
PyroSmart NextGen™ Launch Video
Specializing in chromogenic and turbidimetric reagent technologies, Associates of Cape Cod, Inc. (ACC) has been a global leader in endotoxin…
